Painful burning or numbness in the hands and feet can be a very uncomfortable experience. It can be caused by any number of conditions, from diabetes to peripheral neuropathy. Polycythemia Vera is a rare disorder in which the body produces too many red blood cells, causing thickening of the blood and restricting its flow to the extremities, leading to Painful Burning or Numbness of the Hands or Feet. Fortunately, there are natural treatments for polycythemia vera that may help to reduce symptoms.